Pilot project “Role of Dibutyl Phthalate (DBP) Exposure in Maternal Obesity-induced Fetal Sex-specific Endothelial Dysfunction” starting Feb. 2021
Phthalates are a group of endocrine disruptors that widely existing in the environment. Women at reproductive age have a significant burden of the phthalate congener, di-n-butyl phthalate (DBP). DBP exposure is associated with obesity and adverse pregnancy/fetal outcomes such as preterm birth, fetal growth retardation, and childhood obesity in humans. Although DBP is known as an obesogen, the impact of prenatal DBP exposure on fetal vascular/endothelial development and function in obese pregnancies is unclear. In this study, we will examine the effect of DBP exposure on maternal obesity-induced female and male fetal endothelial dysfunction. Results from this study will provide important information on how phthalates exposure affects placental function as well as the fetal-sex specific programming of fetal vascular/endothelial development and function.
This pilot project is supported by the Southwest Environmental Health Sciences Center at the University of Arizona.